Biomineralized polysaccharide beads for dual-stimuli-responsive drug delivery

Macromol Biosci. 2008 Mar 10;8(3):260-7. doi: 10.1002/mabi.200700177.


Biomineralized polysaccharide-coated alginate beads containing PNIPAAM were prepared. The resulting beads can be used as carriers for sustained pH/temperature-sensitive drug delivery. Characterizations using SEM, EDS, FTIR, and POM revealed that the beads were covered by the calcium-phosphate-mineralized alginate/chitosan membrane. The drug-release behavior was examined using indomethacin as a model drug, and the release profile of the developed materials was found to be responsive to pH and temperature. The release profile could be sustained under neutral conditions, indicating that the mineralized polysaccharide membrane could prevent the permeability of the encapsulated drug and reduce the drug release rate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylic Resins / chemistry*
  • Alginates / chemistry*
  • Delayed-Action Preparations / chemistry
  • Drug Delivery Systems / methods*
  • Glucuronic Acid / chemistry
  • Hexuronic Acids / chemistry
  • Hydrogen-Ion Concentration
  • Indomethacin / chemistry
  • Microscopy, Electron, Scanning
  • Microspheres*
  • Polysaccharides / chemistry*
  • Spectroscopy, Fourier Transform Infrared
  • Temperature


  • Acrylic Resins
  • Alginates
  • Delayed-Action Preparations
  • Hexuronic Acids
  • Polysaccharides
  • poly-N-isopropylacrylamide
  • Glucuronic Acid
  • Indomethacin