Successful treatment of methicillin-resistant Staphylococcus aureus Keratitis with topical ciprofloxacin

Ophthalmology. 1991 Nov;98(11):1690-2. doi: 10.1016/s0161-6420(91)32067-0.


Ciprofloxacin is a new quinolone antibiotic with a broad spectrum of activity against most aerobic gram-positive and gram-negative bacteria. Topical ciprofloxacin (3 mg/ml) was used to treat bacterial keratitis caused by methicillin-resistant strains of Staphylococcus aureus in two patients. Both corneal ulcers had been previously treated with other antibiotics without success. Topical ciprofloxacin was curative in both cases. The authors recommend the use of topical ciprofloxacin for methicillin-resistant S. aureus keratitis.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Topical
  • Aged
  • Aged, 80 and over
  • Ciprofloxacin / therapeutic use*
  • Corneal Ulcer / drug therapy*
  • Corneal Ulcer / microbiology
  • Eye Infections, Bacterial / drug therapy*
  • Female
  • Humans
  • Male
  • Methicillin Resistance*
  • Staphylococcal Infections / drug therapy*
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / isolation & purification
  • Visual Acuity


  • Ciprofloxacin