Low-dose cyclosporine therapy of granulomatous optic neuropathy and orbitopathy

Ophthalmology. 1991 Nov;98(11):1732-6. doi: 10.1016/s0161-6420(91)32064-5.


Four patients with granulomatous disease of the anterior visual pathway presented with optic neuropathy between July 1986 and February 1987, secondary to an orbital pseudotumor (n = 1) and sarcoidosis (n = 3). All but one became resistant to corticosteroid therapy, and all were subsequently treated for 1 to 2 years with low-dose cyclosporine alone or in combination with tapering doses of prednisone. Two patients experienced pronounced recovery of visual function, and visual function was stabilized in the other two; in one of these, magnetic resonance imaging showed substantial regression of intracranial lesions. Steroid-induced complications of uncontrolled hyperglycemia (n = 2) and obesity (n = 4) were controlled with cyclosporine. The authors conclude that low-dose cyclosporine is a safe and effective therapeutic alternative in ocular granulomatous diseases.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cyclosporine / therapeutic use*
  • Female
  • Granuloma / complications
  • Granuloma / drug therapy*
  • Humans
  • Male
  • Middle Aged
  • Optic Nerve Diseases / complications
  • Optic Nerve Diseases / drug therapy*
  • Orbital Diseases / complications
  • Orbital Diseases / drug therapy*
  • Prednisone / adverse effects
  • Uveitis, Anterior / drug therapy
  • Visual Acuity


  • Cyclosporine
  • Prednisone