Abstract
Two new phenylpropanoid-substituted epicatechins, namely, catiguanin A ( 1) and catiguanin B ( 2), were isolated from the bark of Trichilia catigua along with four known compounds, cinchonain Ia ( 3), cinchonain Ib ( 4), cinchonain Ic ( 5), and cinchonain Id ( 6). The structures of 1 and 2 were elucidated by analysis of spectroscopic data and by comparison of their NMR data with those of previously reported cinchonains. The isolated compounds exhibited potent antioxidant activity in the alpha,alpha-diphenyl-beta-picrylhydrazyl (DPPH) radical scavenging test, with IC 50 values in the 2.3-9.4 microM range.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antioxidants* / chemistry
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Antioxidants* / isolation & purification
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Antioxidants* / pharmacology
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Biphenyl Compounds
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Brazil
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Catechin* / analogs & derivatives
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Catechin* / chemistry
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Catechin* / isolation & purification
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Catechin* / pharmacology
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Free Radical Scavengers* / chemistry
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Free Radical Scavengers* / isolation & purification
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Free Radical Scavengers* / pharmacology
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Meliaceae / chemistry*
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Molecular Structure
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Phenylpropionates* / chemistry
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Phenylpropionates* / isolation & purification
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Phenylpropionates* / pharmacology
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Picrates / pharmacology
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Plant Bark / chemistry
Substances
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Antioxidants
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Biphenyl Compounds
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Free Radical Scavengers
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Phenylpropionates
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Picrates
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catiguanin A
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catiguanin B
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Catechin
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1,1-diphenyl-2-picrylhydrazyl