Optimal vitamin D status for the prevention and treatment of osteoporosis

Drugs Aging. 2007;24(12):1017-29. doi: 10.2165/00002512-200724120-00005.

Abstract

Vitamin D(3) (cholecalciferol) sufficiency is essential for maximising bone health. Vitamin D enhances intestinal absorption of calcium and phosphorus. The major source of vitamin D for both children and adults is exposure of the skin to sunlight. Season, latitude, skin pigmentation, sunscreen use, clothing and aging can dramatically influence the synthesis of vitamin D in the skin. Very few foods naturally contain vitamin D or are fortified with vitamin D. Serum 25-hydroxyvitamin D [25(OH)D; calcifediol] is the best measure of vitamin D status. Vitamin D deficiency [as defined by a serum 25(OH)D level of <50 nmol/L (<20 ng/mL)] is pandemic. This deficiency is very prevalent in osteoporotic patients. Vitamin D deficiency causes osteopenia, osteoporosis and osteomalacia, increasing the risk of fracture. Unlike osteoporosis, which is a painless disease, osteomalacia causes aching bone pain that is often misdiagnosed as fibromyalgia or chronic pain syndrome or is simply dismissed as depression. Vitamin D deficiency causes muscle weakness, increasing the risk of falls and fractures, and should be aggressively treated with pharmacological doses of vitamin D. Vitamin D sufficiency can be sustained by sensible sun exposure or ingesting at least 800-1000 IU of vitamin D(3) daily. Patients being treated for osteoporosis should be adequately supplemented with calcium and vitamin D to maximise the benefit of treatment.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aged
  • Bone Density Conservation Agents / metabolism
  • Bone Density Conservation Agents / therapeutic use*
  • Bone and Bones / drug effects
  • Bone and Bones / metabolism
  • Female
  • Fractures, Bone / epidemiology
  • Fractures, Bone / prevention & control
  • Humans
  • Male
  • Nutritional Requirements
  • Osteoporosis* / drug therapy
  • Osteoporosis* / epidemiology
  • Osteoporosis* / prevention & control
  • Osteoporosis, Postmenopausal / drug therapy
  • Osteoporosis, Postmenopausal / epidemiology
  • Osteoporosis, Postmenopausal / prevention & control
  • Prevalence
  • Vitamin D / metabolism
  • Vitamin D / therapeutic use*
  • Vitamin D Deficiency* / drug therapy
  • Vitamin D Deficiency* / epidemiology
  • Vitamin D Deficiency* / prevention & control

Substances

  • Bone Density Conservation Agents
  • Vitamin D