A second-generation autologous chondrocyte implantation approach to the treatment of focal articular cartilage defects

Arthritis Res Ther. 2007;9(5):109. doi: 10.1186/ar2310.


Autologous chondrocyte implantation (ACI) is the most widely used cell-based surgical procedure for the repair of articular cartilage defects. Challenges to successful ACI outcomes include limitation in defect size and geometry as well as inefficient cell retention. Second-generation ACI procedures have thus focused on developing three-dimensional constructs using native and synthetic biomaterials. Clinically significant and satisfactory results from applying autologous chondrocytes seeded in fibrin within a biodegradable polymeric material were recently reported. In the future, third-generation cell-based articular cartilage repair should focus on the use of chondroprogenitor cells and biofunctionalized biomaterials for more extensive and permanent repair.

Publication types

  • Editorial
  • Research Support, N.I.H., Intramural

MeSH terms

  • Animals
  • Cartilage Diseases / pathology
  • Cartilage Diseases / surgery
  • Cartilage, Articular / pathology*
  • Chondrocytes / cytology
  • Chondrocytes / transplantation*
  • Humans
  • Tissue Transplantation / methods
  • Tissue Transplantation / trends
  • Transplantation, Autologous