Hormones, nevi, and melanoma: an approach to the patient

J Am Acad Dermatol. 2007 Dec;57(6):919-31; quiz 932-6. doi: 10.1016/j.jaad.2007.08.045.


For many years, clinicians have been concerned about a potential adverse effect of pregnancy-associated hormones and exogenous hormones on melanocytic nevi and malignant melanoma. Today, these issues are more significant as women have delayed childbearing into their 30's and 40's, and the likelihood of diagnosis with melanoma during pregnancy is enhanced. More recent clinical, epidemiologic, and laboratory studies have shed some light on the relationship among hormones, nevi, and melanoma in pregnancy.

Publication types

  • Review

MeSH terms

  • Dysplastic Nevus Syndrome* / pathology
  • Female
  • Hormones / physiology*
  • Humans
  • Melanoma / etiology*
  • Melanoma / pathology
  • Neoplasm Metastasis
  • Placenta Diseases / etiology
  • Pregnancy
  • Pregnancy Complications, Neoplastic* / pathology
  • Prognosis
  • Receptors, Estrogen / physiology


  • Hormones
  • Receptors, Estrogen