Psoriasis: epidemiology

Clin Dermatol. 2007 Nov-Dec;25(6):535-46. doi: 10.1016/j.clindermatol.2007.08.007.


Psoriasis is a chronic, inflammatory and hyperproliferative skin disease with a genetic basis. While epidermal hyperplasia and altered keratinocyte differentiation are prominent features, considerable evidence indicates that psoriasis is immunologically mediated. Recently, the identification of HLA-Cw6 as the disease allele conferring susceptibility to psoriasis has provided a focus for elucidation of these events. In this article, we will focus on the epidemiology of psoriasis and its associated arthritis.

Publication types

  • Review

MeSH terms

  • Age of Onset
  • Alleles
  • Arthritis, Psoriatic / epidemiology
  • Arthritis, Psoriatic / genetics
  • Genes, MHC Class I
  • Genes, MHC Class II
  • Genetic Predisposition to Disease*
  • Haplotypes
  • Humans
  • Prevalence
  • Psoriasis / epidemiology*
  • Psoriasis / genetics*
  • Risk Factors
  • Sex Factors