Coenzyme Q10 (ubiquinol-10) supplementation improves oxidative imbalance in children with trisomy 21

Pediatr Neurol. 2007 Dec;37(6):398-403. doi: 10.1016/j.pediatrneurol.2007.08.003.

Abstract

Endogenous coenzyme Q10 is an essential cofactor in the mitochondrial respiratory chain, a potent antioxidant, and a potential biomarker for systemic oxidative status. Evidence of oxidative stress was reported in individuals with trisomy 21. In this study, 14 children with trisomy 21 had significantly increased (P < 0.0001) plasma ubiquinone-10 (the oxidized component of coenzyme Q10) compared with 12 age- and sex-matched healthy children (historical controls). Also, the mean ratio of ubiquinol-10 (the biochemically reduced component):total coenzyme Q10 was significantly decreased (P < 0.0001). After 3 months of ubiquinol-10 supplementation (10 mg/kg/day) to 10 patients with trisomy 21, the mean ubiquinol-10:total coenzyme Q10 ratio increased significantly (P < 0.0001) above baseline values, and 80% of individual ratios were within normal range. No significant or unexpected adverse effects were reported by participants. To our knowledge, this is the first study to indicate that the pro-oxidant state in plasma of children with trisomy 21, as assessed by ubiquinol-10:total coenzyme Q10 ratio, may be normalized with ubiquinol-10 supplementation. Further studies are needed to determine whether correction of this oxidant imbalance improves clinical outcomes of children with trisomy 21.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Case-Control Studies
  • Child
  • Coenzymes / blood
  • Coenzymes / therapeutic use
  • Down Syndrome / diet therapy*
  • Down Syndrome / physiopathology*
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Oxidation-Reduction / drug effects*
  • Statistics, Nonparametric
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / blood
  • Ubiquinone / therapeutic use
  • Vitamins / blood
  • Vitamins / therapeutic use*

Substances

  • Coenzymes
  • Vitamins
  • Ubiquinone
  • coenzyme Q10