Tumor microenvironment and immune escape

Surg Oncol Clin N Am. 2007 Oct;16(4):755-74, viii. doi: 10.1016/j.soc.2007.08.004.

Abstract

This article describes the multiple escape mechanisms used by tumor cells to avoid T-cell-mediated recognition and destruction. The discussion focuses on escape mechanisms that may result from changes at the level of TA-specific cytotoxic T lymphocytes and tumor cells in the tumor microenvironment. Specifically, we discuss the negative impact of regulatory T cells and T-cell apoptosis on the tumor antigen-specific cytotoxic T lymphocyte response. We also discuss changes in the expression of histocompatibility antigens by tumor cells, which may affect tumor cell-immune cell interactions.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Apoptosis / immunology
  • CD8 Antigens / immunology
  • HLA Antigens / immunology
  • Humans
  • Models, Biological
  • Neoplasms / immunology*
  • T-Lymphocytes, Cytotoxic / immunology
  • Tumor Escape*

Substances

  • CD8 Antigens
  • HLA Antigens