A current review of ultrasonographic adrenal imaging is presented with emphasis on the clinical and problematic aspects of adrenal disease in the dog. Examples are presented to illustrate the usefulness of ultrasonography in distinguishing between canine pituitary- and adrenal-dependent hyperadrenocorticism. Adrenal imaging in the cat and ferret are discussed briefly. When coordination of sonographic findings with clinical and biochemical results is implemented properly, ultrasonography becomes a powerful and specific diagnostic tool for adrenal disease.