Nramp1 phagocyte intracellular metal withdrawal defense

Microbes Infect. Nov-Dec 2007;9(14-15):1662-70. doi: 10.1016/j.micinf.2007.09.006. Epub 2007 Sep 15.

Abstract

Natural resistance-associated macrophage proteins (Nramp) are multispecific symporters facilitating proton-dependent import of divalent metals. Nramp1 restricts microbial access to essential micro-nutrients such as iron and manganese within professional phagosomes. Increased understanding of Nramp1 roles in human phagocytes will be useful for future therapeutic approaches against selected infectious and immune diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cation Transport Proteins / chemistry
  • Cation Transport Proteins / genetics
  • Cation Transport Proteins / metabolism*
  • Cell Line
  • Eukaryotic Cells / immunology
  • Humans
  • Iron / metabolism*
  • Manganese / metabolism*
  • Mice
  • Molecular Sequence Data
  • Phagocytes / immunology
  • Phagocytes / metabolism*

Substances

  • Cation Transport Proteins
  • natural resistance-associated macrophage protein 1
  • Manganese
  • Iron