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. 2007 Dec;39(12):1440-2.
doi: 10.1038/ng.2007.29. Epub 2007 Nov 18.

Cystatin C Inhibits Amyloid-Beta Deposition in Alzheimer's Disease Mouse Models

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Cystatin C Inhibits Amyloid-Beta Deposition in Alzheimer's Disease Mouse Models

Weiqian Mi et al. Nat Genet. .

Abstract

Using transgenic mice expressing human cystatin C (encoded by CST3), we show that cystatin C binds soluble amyloid-beta peptide and inhibits cerebral amyloid deposition in amyloid-beta precursor protein (APP) transgenic mice. Cystatin C expression twice that of the endogenous mouse cystatin C was sufficient to substantially diminish amyloid-beta deposition. Thus, cystatin C has a protective role in Alzheimer's disease pathogenesis, and modulation of cystatin C concentrations may have therapeutic implications for the disease.

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