Mortality rate in veterans with multiple chronic conditions

J Gen Intern Med. 2007 Dec;22 Suppl 3(Suppl 3):403-7. doi: 10.1007/s11606-007-0277-2.


Background: Among patients with multiple chronic conditions, there is increasing appreciation of the complex interrelatedness of diseases. Previous studies have focused on the prevalence and economic burden associated with multiple chronic conditions, much less is known about the mortality rate associated with specific combinations of multiple diseases.

Objective: Measure the mortality rate in combinations of 11 chronic conditions.

Design: Cohort study of veteran health care users.

Participants: Veterans between 55 and 64 years that used Veterans Health Administration health care services between October 1999 and September 2000.

Measurements: Patients were identified as having one or more of the following: COPD, diabetes, hypertension, rheumatoid arthritis, osteoarthritis, asthma, depression, ischemic heart disease, dementia, stroke, and cancer. Mutually exclusive combinations of disease based on these conditions were created, and 5-year mortality rates were determined.

Results: There were 741,847 persons included. The number in each group by a count of conditions was: none = 217,944 (29.34%); 1 = 221,111 (29.8%); 2 = 175,228 (23.6%); 3 = 86,447 (11.7%); and 4+ = 41,117 (5.5%). The 5-year mortality rate by the number of conditions was: none = 4.1%; 1 = 6.0%; 2 = 7.8%; 3 = 11.2%; 4+ = 16.7%. Among combinations with the same number of conditions, there was significant variability in mortality rates.

Conclusions: Patients with multiple chronic conditions have higher mortality rates. Because there was significant variation in mortality across clusters with the same number of conditions, when studying patients with multiple coexisting illnesses, it is important to understand not only that several conditions may be present but that specific conditions can differentially impact the risk of mortality.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Chronic Disease / economics
  • Chronic Disease / epidemiology
  • Chronic Disease / mortality*
  • Comorbidity*
  • Humans
  • Male
  • Middle Aged
  • United States
  • United States Department of Veterans Affairs
  • Veterans / statistics & numerical data*