CD4+CD25+Foxp3+ regulatory T cells: from basic research to potential therapeutic use

Swiss Med Wkly. 2007 Nov 17;137(45-46):625-34.

Abstract

Regulatory T cells control immune responses to self- and foreign-antigens and play a major role in maintaining the balance between immunity and tolerance. This article reviews recent key developments in the field of CD4+CD25+Foxp3+ regulatory T (TREG) cells. It presents their characteristics and describes their range of activity and mechanisms of action. Some models of diseases triggered by the imbalance between TREG cells and effector pathogenic T cells are described and their potential therapeutic applications in humans are outlined.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, CD / immunology
  • Antigens, Differentiation / immunology
  • CTLA-4 Antigen
  • Forkhead Transcription Factors / immunology
  • Forkhead Transcription Factors / physiology*
  • Forkhead Transcription Factors / therapeutic use
  • Humans
  • Immune Tolerance / physiology
  • Interleukin-10 / immunology
  • Interleukin-10 / physiology
  • Interleukin-2 / immunology
  • Interleukin-2 / physiology
  • Receptors, Interleukin-2 / immunology
  • Receptors, Interleukin-2 / physiology
  • T-Lymphocytes, Regulatory / immunology
  • T-Lymphocytes, Regulatory / physiology*
  • Transforming Growth Factor beta / immunology
  • Transforming Growth Factor beta / physiology
  • Transplantation Immunology

Substances

  • Antigens, CD
  • Antigens, Differentiation
  • CTLA-4 Antigen
  • CTLA4 protein, human
  • FOXP3 protein, human
  • Forkhead Transcription Factors
  • Interleukin-2
  • Receptors, Interleukin-2
  • Transforming Growth Factor beta
  • Interleukin-10