The biological role of dectin-1 in immune response

Int Rev Immunol. Sep-Dec 2007;26(5-6):349-64. doi: 10.1080/08830180701690793.

Abstract

The identification of antigen-recognizing receptors in the innate immune system significantly helped us to understand the initiation and regulation of the innate immune response. Dectin-1 was recently identified as the most important receptor for beta-glucan. Recognition of beta-glucan by dectin-1 triggers effective immune response, including phagocytosis and proinflammatory factor production, to eliminate infecting fungi, which especially benefits immunocompromised patients against opportunistic fungal infection. In addition, dectin-1 is involved in the adaptive immune response as well as autoimmune diseases and immune tolerance. In this paper, we will mainly focus on the characteristics of dectin-1 and its biological role in immune response.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen-Presenting Cells / immunology*
  • Antigen-Presenting Cells / metabolism
  • Cytokines / immunology
  • Cytokines / metabolism*
  • Humans
  • Immunity, Innate
  • Lectins, C-Type
  • Membrane Proteins / chemistry
  • Membrane Proteins / genetics
  • Membrane Proteins / immunology
  • Membrane Proteins / physiology*
  • Mycoses / immunology*
  • Nerve Tissue Proteins / chemistry
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / immunology
  • Nerve Tissue Proteins / physiology*
  • Phagocytosis
  • Protein Isoforms
  • Signal Transduction
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocyte Subsets / metabolism
  • beta-Glucans / immunology
  • beta-Glucans / metabolism*

Substances

  • Cytokines
  • Lectins, C-Type
  • Membrane Proteins
  • Nerve Tissue Proteins
  • Protein Isoforms
  • beta-Glucans
  • dectin 1