Pseudoexfoliation in the Reykjavik Eye Study: prevalence and related ophthalmological variables

Acta Ophthalmol Scand. 2007 Dec;85(8):822-7. doi: 10.1111/j.1600-0420.2007.01051.x.


Purpose: To examine the age and sex-specific prevalence of pseudoexfoliation syndrome (PEX) and its relationship with some ophthalmological variables.

Methods: We carried out a population-based study using a random sample taken from the national population census for citizens of Reykjavik, aged > or = 50 years. A total of 1045 individuals participated in all parts of the study. Pseudoexfoliation was established by slit-lamp examination with a maximally dilated pupil carried out by two experienced ophthalmologists, who were masked to one another's results except in cases of disagreement where they had to reach a consensus.

Results: In all, 108 (10.7%) persons were found to have PEX in at least one eye. Prevalence increased from 2.5% in those aged 50-59 years to 40.6% in those aged > or = 80 years. Women were more frequently affected than men (12.3% versus 8.7%). This difference remained statistically significant after controlling for the effect of age (p < 0.001). Eyes with PEX were found to have higher intraocular pressure (IOP) than eyes without PEX (p < 0.05). However, PEX was not found to be related to central corneal thickness, anterior chamber depth, lens thickness, nuclear lens opacifications or optic disc morphology in a multivariate model.

Conclusions: Pseudoexfoliation is an age-related phenomenon commonly found in Iceland. It is more commonly found in women than in men and is associated with elevated IOP.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Distribution
  • Aged
  • Aged, 80 and over
  • Exfoliation Syndrome / epidemiology*
  • Exfoliation Syndrome / physiopathology*
  • Female
  • Humans
  • Iceland / epidemiology
  • Intraocular Pressure*
  • Male
  • Middle Aged
  • Prevalence
  • Sex Distribution