Marble bone disease: a review of osteopetrosis and its oral health implications for dentists

J Can Dent Assoc. 2007 Nov;73(9):839-43.


Osteopetrosis is one cause of osteosclerosis and may result in such serious oral complications as osteomyelitis and exposed necrotic bone. Dentists should be aware of patients with the disease because of its effect on osteoclast function, which results in impaired wound healing. The purpose of this paper is to review the causes, pathogenesis and differential diagnosis of osteopetrosis and to provide guidance to dentists on the management of patients with osteopetrosis.

Publication types

  • Review

MeSH terms

  • Adult
  • Bone Marrow Transplantation
  • Child
  • Dental Care for Chronically Ill*
  • Dental Caries / etiology
  • Diagnosis, Differential
  • Humans
  • Infant, Newborn
  • Jaw Diseases / etiology*
  • Maxillofacial Abnormalities / etiology
  • Osteoclasts / pathology
  • Osteomyelitis / etiology
  • Osteonecrosis / etiology
  • Osteopetrosis / classification
  • Osteopetrosis / complications*
  • Osteopetrosis / pathology
  • Osteopetrosis / therapy
  • Tooth Abnormalities / etiology