A phylostratigraphy approach to uncover the genomic history of major adaptations in metazoan lineages

Trends Genet. 2007 Nov;23(11):533-9. doi: 10.1016/j.tig.2007.08.014.


Macroevolutionary trends traditionally are studied by fossil analysis, comparative morphology or evo-devo approaches. With the availability of genome sequences and associated data from an increasing diversity of taxa, it is now possible to add an additional level of analysis: genomic phylostratigraphy. As an example of this approach, we use a phylogenetic framework and embryo expression data from Drosophila to show that grouping genes by their phylogenetic origin can uncover footprints of important adaptive events in evolution.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptation, Biological / genetics
  • Animals
  • Drosophila / embryology
  • Drosophila / genetics*
  • Evolution, Molecular*
  • Genome*
  • Phylogeny*