Captopril to mitigate chronic renal failure after hematopoietic stem cell transplantation: a randomized controlled trial

Int J Radiat Oncol Biol Phys. 2008 Apr 1;70(5):1546-51. doi: 10.1016/j.ijrobp.2007.08.041. Epub 2007 Oct 29.


Purpose: To test whether the angiotensin-converting enzyme inhibitor captopril was effective in mitigating chronic renal failure after hematopoietic stem cell transplantation (HSCT).

Methods and materials: A total of 55 subjects undergoing total body irradiation (TBI)-HSCT were enrolled in this randomized controlled trial. Captopril or identical placebo was started at engraftment and continued as tolerated until 1 year after HSCT.

Results: The baseline serum creatinine and calculated glomerular filtration rate (GFR) did not differ between groups. The 1-year serum creatinine level was lower and the GFR higher in the captopril compared with the placebo group (p = 0.07 for GFR). Patient survival was higher in the captopril compared with the placebo group, but this was also not statistically significant (p = 0.09). In study subjects who received the study drug for more than 2 months, the 1-year calculated GFRs were 92 mL/min and 80 mL/min, for the captopril and placebo groups, respectively (p = 0.1). There was no adverse effect on hematologic outcome.

Conclusions: There is a trend in favor of captopril in mitigation of chronic renal failure after radiation-based HSCT.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
  • Captopril / therapeutic use*
  • Child
  • Creatinine / blood
  • Glomerular Filtration Rate
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Kidney Failure, Chronic / drug therapy*
  • Kidney Failure, Chronic / etiology
  • Prospective Studies
  • Statistics, Nonparametric
  • Whole-Body Irradiation / adverse effects*


  • Angiotensin-Converting Enzyme Inhibitors
  • Captopril
  • Creatinine