Effectiveness of mesalamine and propolis in experimental colitis

Adv Ther. Sep-Oct 2007;24(5):1085-97. doi: 10.1007/BF02877715.

Abstract

This study was conducted to investigate the effects of propolis and mesalamine on experimental colitis in rats. Distal colitis was induced in rats by intracolonic instillation of 2 mL of 4% acetic acid. The animals were randomly assigned to 5 groups: group 1, control, (n=8); group 2, colitis, received no treatment (n=8); group 3, colitis+mesalamine, 2 mL once a day via an enema (n=8); group 4, colitis+propolis, 600 mg/kg once a day via intragastric lavage (n=8); and group 5, colitis+mesalamine+propolis for 1 wk (n=8). Levels of nitric oxide were statistically significantly different in comparisons between groups 1 and 2, groups 2 and 3, and groups 4 and 5. Malondialdehyde levels were significantly different when group 2 was compared with groups 3, 4, and 5. A significant difference was observed when group 3 was compared with group 4 for myeloperoxidase. Most propolis-treated rats had normal histology; mesalamine-treated and propolis+mesalamine-treated rats had inflammatory cell infiltration at rates of 50% and 33%, respectively. The investigators concluded that propolis and mesalamine are efficient independently and in combination, but that their combined effect was not observed to be additive in experimental colitis.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / therapeutic use*
  • Colitis / drug therapy*
  • Colitis / metabolism
  • Colitis / pathology
  • Drug Therapy, Combination
  • Male
  • Malondialdehyde / metabolism
  • Mesalamine / therapeutic use*
  • Nitric Oxide / metabolism
  • Peroxidase / metabolism
  • Propolis / therapeutic use*
  • Rats
  • Rats, Wistar

Substances

  • Anti-Inflammatory Agents
  • Nitric Oxide
  • Mesalamine
  • Malondialdehyde
  • Propolis
  • Peroxidase