The impact of 8-aryl-and 8-heteroaryl-2'-deoxyguanosine derivatives on G-quadruplex formation

Nucleic Acids Symp Ser (Oxf). 2007;(51):39-40. doi: 10.1093/nass/nrm020.

Abstract

Guanine and G-rich oligonucleotides are known to self-assemble in the presence of a variety of cations to form higher ordered structures known as Gquadruplexes. We have synthesized a library of 8-aryl/heteroaryl-2'-deoxyguanosine derivatives (8ArGs) that are also able to self-assemble into quadruplex structures. We demonstrate that the properties of such quadruplexes can be modulated by the nature of the groups attached to the guanine base. These supramolecules are potentially useful in the development of self-assembled nanodevices.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Deoxyguanosine / analogs & derivatives*
  • Deoxyguanosine / chemistry
  • G-Quadruplexes*
  • Nanostructures / chemistry
  • Nuclear Magnetic Resonance, Biomolecular
  • Potassium / chemistry

Substances

  • Deoxyguanosine
  • Potassium