Bactericidal antibiotics and oxidative stress: a radical proposal

ACS Chem Biol. 2007 Nov 20;2(11):708-10. doi: 10.1021/cb700232k.


A recent publication suggests that many antibiotics exert their bactericidal effects via the production of hydroxyl radicals, regardless of their molecular targets. This proposal represents an abrupt departure from conventional models, and it will attract further experimental tests.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Cells, Cultured
  • Hydroxyl Radical
  • Oxidative Stress / drug effects*


  • Anti-Bacterial Agents
  • Hydroxyl Radical