Ubiquitous plasticity and memory storage

Neuron. 2007 Nov 21;56(4):582-92. doi: 10.1016/j.neuron.2007.10.030.


To date, most hypotheses of memory storage in the mammalian brain have focused upon long-term synaptic potentiation and depression (LTP and LTD) of fast glutamatergic excitatory postsynaptic currents (EPSCs). In recent years, it has become clear that many additional electrophysiological components of neurons, from electrical synapses to glutamate transporters to voltage-sensitive ion channels, can also undergo use-dependent long-term plasticity. Models of memory storage that incorporate this full range of demonstrated electrophysiological plasticity are better able to account for both the storage of memory in neuronal networks and the complexities of memory storage, indexing, and recall as measured behaviorally.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain / physiology*
  • Brain / ultrastructure
  • Excitatory Postsynaptic Potentials / physiology
  • Humans
  • Long-Term Potentiation / physiology
  • Long-Term Synaptic Depression / physiology
  • Memory / physiology*
  • Neuronal Plasticity / physiology*
  • Receptors, Glutamate / physiology*
  • Signal Transduction / physiology
  • Synaptic Transmission / physiology*


  • Receptors, Glutamate