Parental history of type 2 diabetes in patients with nonaffective psychosis

Schizophr Res. 2008 Jan;98(1-3):302-6. doi: 10.1016/j.schres.2007.10.002. Epub 2007 Nov 26.


Introduction: We attempted to replicate two previous studies which found an increased risk of diabetes in the relatives of schizophrenia probands.

Methods: N=34 patients with newly-diagnosed nonaffective psychosis and N=52 non-psychiatric controls were interviewed for parental history of Type 2 diabetes.

Results: In a logistic regression model that included multiple potential confounders, psychosis was a significant predictor of Type 2 diabetes in either parent (p<0.04).

Discussion: We found an increased prevalence of Type 2 diabetes in the parents of nonaffective psychosis subjects. This association may be due to shared environmental or genetic risk factors, or both.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Child
  • Child of Impaired Parents*
  • Diabetes Mellitus, Type 2 / diagnosis
  • Diabetes Mellitus, Type 2 / epidemiology*
  • Diabetes Mellitus, Type 2 / genetics
  • Family*
  • Female
  • Genetic Predisposition to Disease / genetics
  • Humans
  • Logistic Models
  • Male
  • Maternal Age
  • Models, Statistical
  • Parents / psychology*
  • Paternal Age
  • Prevalence
  • Risk Factors
  • Schizophrenia / epidemiology*
  • Schizophrenia / genetics
  • Schizophrenic Psychology
  • Social Environment