Induction of particle polymorphism by cucumber necrosis virus coat protein mutants in vivo

J Virol. 2008 Feb;82(3):1547-57. doi: 10.1128/JVI.01976-07. Epub 2007 Nov 21.

Abstract

The Cucumber necrosis virus (CNV) particle is a T=3 icosahedron consisting of 180 identical coat protein (CP) subunits. Plants infected with wild-type CNV accumulate a high number of T=3 particles, but other particle forms have not been observed. Particle polymorphism in several T=3 icosahedral viruses has been observed in vitro following the removal of an extended N-terminal region of the CP subunit. In the case of CNV, we have recently described the structure of T=1 particles that accumulate in planta during infection by a CNV mutant (R1+2) in which a large portion of the N-terminal RNA binding domain (R-domain) has been deleted. In this report we further describe properties of this mutant and other CP mutants that produce polymorphic particles. The T=1 particles produced by R1+2 mutants were found to encapsidate a 1.9-kb RNA species as well as smaller RNA species that are similar to previously described CNV defective interfering RNAs. Other R-domain mutants were found to encapsidate a range of specifically sized less-than-full-length CNV RNAs. Mutation of a conserved proline residue in the arm domain near its junction with the shell domain also influenced T=1 particle formation. The proportion of polymorphic particles increased when the mutation was incorporated into R-domain deletion mutants. Our results suggest that both the R-domain and the arm play important roles in the formation of T=3 particles. In addition, the encapsidation of specific CNV RNA species by individual mutants indicates that the R-domain plays a role in the nature of CNV RNA encapsidated in particles.

MeSH terms

  • Capsid Proteins / genetics*
  • Electrophoresis, Agar Gel
  • Microscopy, Electron, Transmission
  • Mutant Proteins / genetics
  • RNA, Viral / genetics*
  • RNA, Viral / isolation & purification
  • Tombusvirus / chemistry*
  • Tombusvirus / genetics
  • Tombusvirus / ultrastructure*
  • Virion / chemistry*
  • Virion / genetics
  • Virion / ultrastructure*

Substances

  • Capsid Proteins
  • Mutant Proteins
  • RNA, Viral