Effects of a preoperative femoral nerve block on pain management and rehabilitation after total knee arthroplasty

Am J Orthop (Belle Mead NJ). 2007 Oct;36(10):554-7.


The objective of this prospective, randomized, double-blind study was to determine if preoperative administration of a femoral nerve block reduces the amount of morphine needed for postoperative analgesia after total knee arthroplasty (TKA). Forty-two patients undergoing TKA were randomly assigned to receive either a femoral nerve block (0.50% bupivacaine hydrochloride with epinephrine 1:200,000) or matching placebo. Results showed postoperative morphine use was significantly lower in patients who received the nerve block (25.5 vs 37.5 mg, P = .016); however, the 2 groups had similar pain scores and rehabilitative outcomes. In general, a preoperative femoral nerve block is a safe and effective adjunct for decreasing morphine use for post-TKA analgesia.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Anesthetics, Local / administration & dosage
  • Arthroplasty, Replacement, Knee / rehabilitation*
  • Bupivacaine / administration & dosage
  • Double-Blind Method
  • Epinephrine / administration & dosage
  • Female
  • Femoral Nerve*
  • Humans
  • Male
  • Middle Aged
  • Nerve Block / methods*
  • Pain / prevention & control*
  • Pain Measurement
  • Postoperative Complications
  • Preoperative Care*
  • Prospective Studies
  • Range of Motion, Articular
  • Statistics, Nonparametric
  • Treatment Outcome
  • Vasoconstrictor Agents / administration & dosage


  • Anesthetics, Local
  • Vasoconstrictor Agents
  • Bupivacaine
  • Epinephrine