Cytochrome c biogenesis in mitochondria

Mitochondrion. 2008 Jan;8(1):61-73. doi: 10.1016/j.mito.2007.10.001. Epub 2007 Oct 11.


As part of the respiratory chain, c-type cytochromes are essential electron transporters. They are characterized by the covalent attachment of a heme prosthetic group. The biogenesis of these proteins includes all the processes leading to this fixation. Yeast and animals have evolved a comparatively simple mechanism relying on cytochrome c heme lyases. In contrast, plant mitochondria have kept a maturation pathway inherited from their prokaryote ancestor. It involves Ccm proteins encoded in both the nuclear and the mitochondrial genomes of plants. These proteins compose a heme delivery pathway, include an ABC transporter, a redox protein and a putative heme lyase.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • ATP-Binding Cassette Transporters / genetics*
  • ATP-Binding Cassette Transporters / physiology
  • Bacteria / enzymology
  • Cytochromes c / biosynthesis
  • Cytochromes c / genetics*
  • Evolution, Molecular
  • Genome, Bacterial
  • Genome, Fungal
  • Genome, Plant
  • Heme / metabolism
  • Lyases / genetics
  • Lyases / physiology
  • Mitochondria / enzymology*
  • Plants / enzymology
  • Plants / genetics*


  • ATP-Binding Cassette Transporters
  • Heme
  • Cytochromes c
  • Lyases
  • cytochrome C synthetase