Innovations in image-guided radiotherapy

Nat Rev Cancer. 2007 Dec;7(12):949-60. doi: 10.1038/nrc2288.


The limited ability to control for the location of a tumour compromises the accuracy with which radiation can be delivered to tumour-bearing tissue. The resultant requirement for larger treatment volumes to accommodate target uncertainty restricts the radiation dose because more surrounding normal tissue is exposed. With image-guided radiotherapy (IGRT) these volumes can be optimized and tumoricidal doses can be delivered, achieving maximal tumour control with minimal complications. Moreover, with the ability of high-precision dose delivery and real-time knowledge of the target volume location, IGRT has initiated the exploration of new indications for radiotherapy, some of which were previously considered infeasible.

Publication types

  • Review

MeSH terms

  • Equipment Design
  • Humans
  • Neoplasms / radiotherapy*
  • Radiation Dosage
  • Radiation Oncology / instrumentation
  • Radiation Oncology / methods
  • Radiation Oncology / trends
  • Radiotherapy, Conformal / instrumentation
  • Radiotherapy, Conformal / methods*
  • Radiotherapy, Conformal / trends*
  • Radiotherapy, Intensity-Modulated / instrumentation
  • Radiotherapy, Intensity-Modulated / methods
  • Tomography, X-Ray Computed / instrumentation
  • Tomography, X-Ray Computed / methods