The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people

J Int Med Res. 2007 Nov-Dec;35(6):900-8. doi: 10.1177/147323000703500620.


The results from a clinical study performed in 12 healthy volunteers with different coffee products containing glucose show that instant coffee enriched with chlorogenic acid induced a reduction in the absorption of glucose of 6.9% compared with the control. No such effects were seen with normal or decaffeinated instant coffee. In a second, comparative, randomized, double-blind, 12-week study we investigated the effect on the body mass of 30 overweight people, compared with normal instant coffee. The average losses in mass in the chlorogenic acid enriched and normal instant coffee groups were 5.4 and 1.7 kg, respectively. We conclude that chlorogenic acid enriched instant coffee appears to have a significant effect on the absorption and utilization of glucose from the diet. This effect, if the coffee is used for an extended time, may result in reduced body mass and body fat when compared with the use of normal instant coffee.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged, 80 and over
  • Body Composition / drug effects*
  • Child
  • Chlorogenic Acid* / administration & dosage
  • Chlorogenic Acid* / pharmacology
  • Coffee / chemistry*
  • Female
  • Glucose / metabolism*
  • Humans
  • Intestinal Absorption / drug effects
  • Male
  • Obesity* / drug therapy
  • Obesity* / metabolism
  • Overweight* / drug therapy
  • Overweight* / metabolism


  • Coffee
  • Chlorogenic Acid
  • Glucose