Size at birth, infant growth, and blood pressure at three years of age

J Pediatr. 2007 Dec;151(6):670-4. doi: 10.1016/j.jpeds.2007.05.010. Epub 2007 Aug 10.


Objectives: Our aim was to determine the extent to which infant growth-in weight-for-length-from birth to 6 months is associated with systolic blood pressure (SBP) at 3 years and to determine whether this association varies with birth size.

Study design: In 530 children from the prospective cohort Project Viva, we measured birth length and 6-month weight and length with research standard instruments and SBP at age 3 years with a Dinamap automated recorder. We derived weight-for-length z-scores (WFL-z) and analyzed data with mixed effects regression models.

Results: The mean (SD) WFL-z was 0.47 (0.75) at birth and 0.70 (0.96) at 6 months. Mean (SD) SBP at 3 years was 91.7 (9.4) mm Hg. After adjusting for confounding variables and birth WFL-z, child SBP was 1.0 mm Hg (95% CI 0.2, 1.8) higher for each z-score increment in 6-month WFL-z. The SBP of children in the lowest birth WFL-z quartile and the highest 6-month WFL-z quartile was 5.5 mm Hg (95% CI 2.6, 8.4) higher than that of children in the highest birth and lowest 6-month WFL-z quartiles.

Conclusions: More rapid increase in weight-for-length, a measure of adiposity, in the first 6 months of life is associated with higher early childhood SBP, particularly in children who are thin at birth.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Birth Weight / physiology*
  • Blood Pressure*
  • Body Height
  • Body Mass Index
  • Child, Preschool
  • Cohort Studies
  • Growth / physiology
  • Humans
  • Infant
  • Infant, Newborn / growth & development*
  • Weight Gain / physiology*