Mechanisms controlling cell cycle exit upon terminal differentiation

Curr Opin Cell Biol. 2007 Dec;19(6):697-704. doi: 10.1016/ Epub 2007 Nov 26.


Coordinating terminal differentiation with permanent exit from the cell cycle is crucial for proper organogenesis, yet how the cell cycle is blocked in differentiated tissues remains unclear. Important roles for retinoblastoma family proteins and Cyclin-dependent kinase inhibitors have been delineated, but in many cases it remains unclear what triggers cell cycle exit. This review focuses on describing recent advances in deciphering how terminal differentiation and exit from the cell cycle are coordinated.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology*
  • Cell Differentiation / physiology*
  • Gene Expression Regulation*
  • Humans
  • Signal Transduction*