A Better Fluorescent Protein for Whole-Body Imaging

Trends Biotechnol. 2008 Jan;26(1):1-4. doi: 10.1016/j.tibtech.2007.10.006. Epub 2007 Nov 26.

Abstract

Whole-body imaging with fluorescent proteins is a powerful technology with many applications in small animals. Brighter, red-shifted proteins can make whole-body imaging more sensitive owing to reduced absorption by tissues and less scatter. A new protein called Katushka has been isolated. It is the brightest known protein with emission at wavelengths longer than 620 nm. This new protein offers the potential for noninvasive whole-body imaging of numerous cellular and molecular processes in live animals.

MeSH terms

  • Animals
  • Green Fluorescent Proteins
  • Luminescent Proteins / metabolism*
  • Mice
  • Mice, Nude
  • Whole Body Imaging / methods*

Substances

  • Luminescent Proteins
  • red fluorescent protein
  • Green Fluorescent Proteins