Proteases in parasitic diseases

Annu Rev Pathol. 2006;1:497-536. doi: 10.1146/annurev.pathol.1.110304.100151.


Parasitic diseases represent major global health problems of immense proportion. Schistosomiasis, malaria, leishmaniasis, Chagas disease, and African sleeping sickness affect hundreds of millions of people worldwide, cause millions of deaths annually, and present an immense social and economic burden. Recent advances in genomic analysis of several of the major global parasites have revealed key factors involved in the pathogenesis of parasite diseases. Among the major virulence factors identified are parasite-derived proteases. This review focuses on the direct role of proteases in disease pathogenesis. Well-characterized examples of the roles proteases play in pathogenesis include their involvement in invasion of the host by parasite migration through tissue barriers, degradation of hemoglobin and other blood proteins, immune evasion, and activation of inflammation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Host-Parasite Interactions / physiology*
  • Humans
  • Parasites / pathogenicity*
  • Parasitic Diseases / enzymology*
  • Parasitic Diseases / immunology
  • Parasitic Diseases / pathology
  • Peptide Hydrolases / immunology
  • Peptide Hydrolases / metabolism*
  • Protease Inhibitors / metabolism
  • Virulence


  • Protease Inhibitors
  • Peptide Hydrolases