Role of stress response sigma factor SigG in Mycobacterium tuberculosis

J Bacteriol. 2008 Feb;190(3):1128-33. doi: 10.1128/JB.00511-07. Epub 2007 Nov 26.


The sigG gene of Mycobacterium tuberculosis was disrupted by homologous recombination, and the genes regulated by SigG were examined by real-time reverse-transcription PCR and microarray studies. The SigG consensus promoter recognition sequence was identified as GCGNGT-N15-18-CGANCA. A DeltasigG mutant was found to be more resistant to mitomycin C treatment than the wild-type strain, indicating that it may be involved in the SOS response in M. tuberculosis.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Base Sequence
  • Cell Line
  • DNA-Directed RNA Polymerases / genetics
  • DNA-Directed RNA Polymerases / metabolism*
  • Gene Expression Regulation, Bacterial*
  • Heat-Shock Response*
  • Humans
  • Macrophages, Alveolar / microbiology
  • Mice
  • Molecular Sequence Data
  • Mycobacterium tuberculosis / metabolism
  • Mycobacterium tuberculosis / pathogenicity
  • Mycobacterium tuberculosis / physiology*
  • Oligonucleotide Array Sequence Analysis
  • Promoter Regions, Genetic
  • Recombination, Genetic
  • Reverse Transcriptase Polymerase Chain Reaction
  • SOS Response, Genetics*
  • Sigma Factor / genetics
  • Sigma Factor / metabolism*


  • Bacterial Proteins
  • Sigma Factor
  • RNA polymerase sigma 70
  • DNA-Directed RNA Polymerases