Non-invasive ventilation reduces respiratory tract infections in children with neuromuscular disorders

Pediatr Pulmonol. 2008 Jan;43(1):67-71. doi: 10.1002/ppul.20740.


Non-invasive ventilation (NIV) has been shown to improve gas exchange and survival in patients with chronic neuromuscular disorders. Little is known about its influence on respiratory tract infections (RTIs). Twenty-four patients with regular use of NIV and 11 patients without NIV with neuromuscular disorders answered a questionnaire concerning the use of NIV and assisted coughing techniques, the status of influenza and pneumococcus vaccination, and the frequency and severity of RTIs. Additionally, we performed a retrospective chart review of twelve patients who were ventilated over a period of at least 5 years. In the first year of NIV consultations of a general practitioner due to RTI decreased from 9.2+/-20.8 to 3.2+/-5.3 per year (P<0.005), the number of antibiotic treatment due to RTI decreased from 4.1+/-3.4 to 1.9+/-2.2 per year (P<0.005) and the number of hospital admissions due to RTI decreased from 1.6+/-1.7 to 0.7+/-1.3 per year (P<0.005). Vaccinations against influenza and/or pneumococcus did not have a significant influence on the rate of infections. In 12 patients using NIV for more than 5 years the incidence of RTI requiring hospital admission decreased from 0.54+/-0.41/year in the pre-ventilation period to 0.12+/-0.09/year in the NIV period (P<0.005). NIV had a favorable impact on respiratory infectious complications in children with neuromuscular disorders.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Anti-Bacterial Agents / therapeutic use
  • Child
  • Drug Prescriptions / statistics & numerical data
  • Hospitalization / statistics & numerical data
  • Humans
  • Influenza Vaccines / therapeutic use
  • Neuromuscular Diseases / physiopathology*
  • Neuromuscular Diseases / therapy*
  • Physicians, Family / statistics & numerical data
  • Pneumococcal Vaccines / therapeutic use
  • Positive-Pressure Respiration / statistics & numerical data*
  • Respiratory Muscles / physiopathology
  • Respiratory Tract Infections / drug therapy
  • Respiratory Tract Infections / epidemiology*
  • Respiratory Tract Infections / prevention & control
  • Retrospective Studies
  • Surveys and Questionnaires
  • Treatment Outcome


  • Anti-Bacterial Agents
  • Influenza Vaccines
  • Pneumococcal Vaccines