Retail meat consumption and the acquisition of antimicrobial resistant Escherichia coli causing urinary tract infections: a case-control study

Foodborne Pathog Dis. Winter 2007;4(4):419-31. doi: 10.1089/fpd.2007.0026.

Abstract

Background: The increasing incidence of community-acquired urinary tract infections (UTIs) caused by antimicrobial resistant Escherichia coli, and observations of potential outbreaks of UTI-causing E. coli, suggest that food may be an important source of E. coli in women who develop UTI. We sought to determine if acquisition of and infection with a UTI-causing, antimicrobial resistant E. coli isolate is associated with a woman's dietary habits, specifically her preparation and consumption of retail meat products.

Methods: Between April 2003 and June 2004, a case-control study was conducted. The dietary habits of women with UTI caused by an antimicrobial resistant E. coli (cases) and women with UTI caused by fully susceptible E. coli (controls) were compared. Broth microdilution was used to perform antimicrobial resistance testing. All E. coli isolates were genotyped by the pulsed-field gel electrophoresis (PFGE) method.

Results: Ninety-nine women met study criteria. Women who were infected with multidrug-resistant E. coli reported more frequent chicken consumption (adjusted OR = 3.7, 95% CI 1.1, 12.4). Women with UTI caused by an ampicillin- or cephalosporin-resistant E. coli isolate reported more frequent consumption of pork (adjusted OR = 3.2, 95% CI 1.0, 10.3 and adjusted OR = 4.0, 95% CI 1.0, 15.5, respectively). Frequent alcohol consumption was associated with antimicrobial resistant UTI.

Conclusions: This study provides epidemiologic evidence that antimicrobial resistant, UTI-causing E. coli could have a food reservoir, possibly in poultry or pork.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Alcohol Drinking / adverse effects
  • Animals
  • Case-Control Studies
  • Chickens
  • Confidence Intervals
  • Disease Reservoirs / microbiology
  • Drug Resistance, Bacterial
  • Escherichia coli / drug effects*
  • Escherichia coli / growth & development
  • Escherichia coli Infections / drug therapy*
  • Escherichia coli Infections / microbiology
  • Escherichia coli Infections / transmission
  • Feeding Behavior*
  • Female
  • Humans
  • Meat / microbiology*
  • Middle Aged
  • Odds Ratio
  • Species Specificity
  • Swine
  • Urinary Tract Infections / drug therapy*
  • Urinary Tract Infections / microbiology