Two-mutation model for carcinogenesis: joint analysis of premalignant and malignant lesions

Math Biosci. 1991 Apr;104(1):97-109. doi: 10.1016/0025-5564(91)90032-e.


A model for carcinogenesis that postulates two rate-limiting events for malignant transformation is a generalization of the recessive oncogenesis hypothesis, according to which inactivation of homologous tumor suppressor genes leads to cancer. This model has been shown to be consistent with a large body of epidemiologic and experimental data and has recently been used for the analysis of altered hepatic foci in rodents. These foci are considered to be premalignant lesions. In this paper the necessary mathematics for the joint analysis of premalignant and malignant lesions are developed within the framework of this model.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic
  • Genes, Recessive
  • Genes, Tumor Suppressor
  • Humans
  • Liver Neoplasms / genetics
  • Mathematics
  • Models, Genetic*
  • Neoplasms / genetics*
  • Oncogenes*
  • Precancerous Conditions / genetics*
  • Probability