Anti-inflammatory effects of low-intensity extremely high-frequency electromagnetic radiation: frequency and power dependence

Bioelectromagnetics. 2008 Apr;29(3):197-206. doi: 10.1002/bem.20381.


Using a model of acute zymosan-induced footpad edema in NMRI mice, the frequency and power dependence of anti-inflammatory effect of low-intensity extremely high-frequency electromagnetic radiation (EHF EMR) was found. Single whole-body exposure of animals to EHF EMR at the intensity of 0.1 mW/cm(2) for 20 min at 1 h after zymosan injection reduced both the footpad edema and local hyperthermia on average by 20% at the frequencies of 42.2, 51.8, and 65 GHz. Some other frequencies from the frequency range of 37.5-70 GHz were less effective or not effective at all. At fixed frequency of 42.2 GHz and intensity of 0.1 mW/cm(2), the effect had bell-shaped dependence on exposure duration with a maximum at 20-40 min. Reduction of intensity to 0.01 mW/cm(2) resulted in a change of the effect dependence on exposure duration to a linear one. Combined action of cyclooxygenase inhibitor sodium diclofenac and EHF EMR exposure caused a partial additive effect of decrease in footpad edema. Combined action of antihistamine clemastine and EHF EMR exposure caused a dose-dependent abolishment of the anti-inflammatory effect of EHF EMR. The results obtained suggest that arachidonic acid metabolites and histamine are involved in realization of anti-inflammatory effects of low-intensity EHF EMR.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / administration & dosage*
  • Dose-Response Relationship, Radiation
  • Edema / chemically induced
  • Edema / drug therapy*
  • Edema / radiotherapy*
  • Inflammation / chemically induced
  • Inflammation / drug therapy*
  • Inflammation / radiotherapy*
  • Male
  • Mice
  • Microwaves / therapeutic use*
  • Radiation Dosage
  • Treatment Outcome
  • Zymosan


  • Anti-Inflammatory Agents
  • Zymosan