Privileged structures: a useful concept for the rational design of new lead drug candidates

Mini Rev Med Chem. 2007 Nov;7(11):1108-19. doi: 10.2174/138955707782331722.

Abstract

Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications. In the present work, we describe some examples and applications of the usefulness of the privileged structure concept for the structural design of new drug candidates, by discussing the eligibility of such motifs, including the identification of the N-acylhydrazone template as privileged structures.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Benzodiazepines / chemistry
  • Dihydropyridines / chemistry
  • Drug Design*
  • Humans
  • Hydrazones / chemistry*
  • Hydrazones / classification
  • Molecular Structure
  • Pharmaceutical Preparations / chemistry
  • Pyridazines / chemistry
  • Receptors, Cell Surface / chemistry
  • Receptors, Cell Surface / drug effects
  • Spiro Compounds / chemistry
  • Structure-Activity Relationship*
  • Terminology as Topic

Substances

  • Dihydropyridines
  • Hydrazones
  • Pharmaceutical Preparations
  • Pyridazines
  • Receptors, Cell Surface
  • Spiro Compounds
  • aminopyridazine
  • Benzodiazepines