Synthesis and anti-peptic activity of compounds related to the metabolites of sodium 3-ethyl-7-isopropyl-1-azulenesulfonate (KT1-32)

Chem Pharm Bull (Tokyo). 1991 Sep;39(9):2429-32. doi: 10.1248/cpb.39.2429.

Abstract

The metabolites of sodium 3-ethyl-7-isopropyl-1-azulenesulfonate (KT1-32, 1), a candidate as an anti-ulcer drug, and related compounds were synthesized. The effects of the compounds on anti-peptic activity were determined as compared to that of 1.

Publication types

  • Comparative Study

MeSH terms

  • Anti-Ulcer Agents / chemical synthesis*
  • Anti-Ulcer Agents / pharmacology
  • Azulenes
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / metabolism*
  • Sesquiterpenes / pharmacology

Substances

  • Anti-Ulcer Agents
  • Azulenes
  • Sesquiterpenes
  • azuletil