Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 43 (8), 1639-47

N6-1,3-diphenylurea Derivatives of 2-phenyl-9-benzyladenines and 8-azaadenines: Synthesis and Biological Evaluation as Allosteric Modulators of A2A Adenosine Receptors

Affiliations

N6-1,3-diphenylurea Derivatives of 2-phenyl-9-benzyladenines and 8-azaadenines: Synthesis and Biological Evaluation as Allosteric Modulators of A2A Adenosine Receptors

Irene Giorgi et al. Eur J Med Chem.

Abstract

Some 1-[4-(9-benzyl-2-phenyl-9H-purin-6-ylamino)-phenyl]-3-phenyl-urea derivatives and some 1-[4-(9-benzyl-2-phenyl-9H-8-azapurin-6-ylamino)-phenyl]-3-phenyl-urea derivatives were synthesised and evaluated for their interaction with adenosine receptors. It was found that some of these compounds can act as positive enhancers of agonist and antagonist radioligands for the A(2A) adenosine receptors. This evidence was also strengthened by functional data. Other compounds can act as negative modulators. Furthermore these compounds show inhibitory properties for A(1) and A(3) adenosine receptors.

Similar articles

See all similar articles

Cited by 5 articles

Publication types

LinkOut - more resources

Feedback