The universal protein resource (UniProt)

Nucleic Acids Res. 2008 Jan;36(Database issue):D190-5. doi: 10.1093/nar/gkm895. Epub 2007 Nov 27.


The Universal Protein Resource (UniProt) provides a stable, comprehensive, freely accessible, central resource on protein sequences and functional annotation. The UniProt Consortium is a collaboration between the European Bioinformatics Institute (EBI), the Protein Information Resource (PIR) and the Swiss Institute of Bioinformatics (SIB). The core activities include manual curation of protein sequences assisted by computational analysis, sequence archiving, development of a user-friendly UniProt website, and the provision of additional value-added information through cross-references to other databases. UniProt is comprised of four major components, each optimized for different uses: the UniProt Knowledgebase, the UniProt Reference Clusters, the UniProt Archive and the UniProt Metagenomic and Environmental Sequences database. UniProt is updated and distributed every three weeks, and can be accessed online for searches or download at

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Databases, Protein*
  • Genomics
  • Internet
  • Proteins / analysis
  • Proteins / genetics
  • Proteins / physiology
  • Sequence Analysis, Protein*
  • Systems Integration
  • User-Computer Interface
  • Viral Proteins / chemistry


  • Proteins
  • Viral Proteins