Does hyperbaric oxygen administration decrease side effect and improve quality of life after pelvic radiation?

Acta Med Indones. Oct-Dec 2007;39(4):169-73.


Aim: to evaluate the influence of HBOT to the side effect and quality of life after pelvic radiation.

Methods: this is an open randomized, parallel, prospective study conducted in Department of Obstetrics and Gynecology, Oncology Division and Department of Radiotherapy. Endoscopy procedure was performed in Department of Internal Medicine and tissue biopsy in Department of Pathology Anatomy. The hyperbaric oxygen therapy (HBOT) was done in Dr. Mintohardjo, Navy Seal Hospital Jakarta. The side effect was measured using LENT SOMA scale ratio, the quality of life used the Karnofsky score. The difference of two mean was analyzed using student t test.

Results: of 32 patients undergoing HBOT and 33 patients as control, the ratio of ASE of control group was 44.1+/-28.2%, HBOT group was 0.7+/-30.1%; p<0.001; the LSE of control group was 33.6+/-57.6%, HBOT group was -19.6+/-69.4%; p=0.008. Quality of life of control group after intervention was 4.5+/-10.7%; HBOT group was 19.7+/-9.6%; p <0.001. After 6 months of intervention the quality of life was 2.5+/-16.1% in the control group, and HBOT group was 15.2+/-14.7%; p =0.007.

Conclusion: the study showed that HBOT decreased acute and late side effect, also improved the quality of life of patients with proctitis radiation.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Female
  • Genital Neoplasms, Female / radiotherapy*
  • Humans
  • Hyperbaric Oxygenation*
  • Karnofsky Performance Status
  • Male
  • Middle Aged
  • Oxygen / administration & dosage
  • Oxygen / therapeutic use*
  • Pelvis / radiation effects*
  • Proctitis / prevention & control*
  • Prospective Studies
  • Quality of Life*
  • Radiation Injuries / etiology
  • Radiation Injuries / prevention & control*
  • Radiotherapy / adverse effects
  • Risk Factors


  • Oxygen