Amnioinfusion in preterm PROM: effects on amnion and cord histology

J Perinatol. 2008 Feb;28(2):97-101. doi: 10.1038/ Epub 2007 Nov 29.


Objective: To investigate the effects of transabdominal amnioinfusion (TA) on the histology of amnion (A) and umbilical cord (UC).

Study design: From a cohort of 56 singleton pregnancies with premature rupture of membranes (PROM) at <or=24.6 weeks, we excluded those who did not develop severe oligohydramnios (n=12). Of the 44 patients, 29 consented to TA and 15 declined the procedure. TA was performed with normal saline solution.

Result: Women who consented to TA underwent a median of three procedures had a gestational age at PROM of 18.7 weeks and at delivery of 26.1 weeks, with a latency of 50 days. Compared with subjects who declined the procedure, TA had a beneficial effect on clinical variables, mediated primarily by a longer latency. TA was not associated with identifiable effects on the histologic features of A or UC.

Conclusion: A and UC histology is not significantly affected by exposure to saline solution even for prolonged periods of time.

MeSH terms

  • Adult
  • Amnion / pathology*
  • Amniotic Fluid
  • Chorion / pathology
  • Epithelial Cells
  • Female
  • Fetal Membranes, Premature Rupture
  • Humans
  • Oligohydramnios / pathology
  • Oligohydramnios / therapy
  • Placental Circulation / physiology
  • Pregnancy
  • Pregnancy Outcome
  • Pregnancy Trimester, Second
  • Sodium Chloride / administration & dosage*
  • Umbilical Cord / pathology*


  • Sodium Chloride