Pregnancy Outcomes in Women Using Inhaled Fluticasone During Pregnancy: A Case Series

Allergol Immunopathol (Madr). Nov-Dec 2007;35(6):239-42. doi: 10.1157/13112989.

Abstract

Background: The aim of the study was to report the maternal and fetal outcomes of women with respiratory illnesses who were treated with inhaled fluticasone during pregnancy.

Material and methods: We identified 12 cases treated with inhaled fluticasone during pregnancy out of women who received obstetric and teratogen-risk evaluation at the Korean Motherisk Program. A detailed medical and obstetric history was obtained and cases were followed-up until either spontaneous or voluntary pregnancy termination or delivery occurred.

Results: None of the participants had any obstetric complication. However, in addition to fluticasone, most of the 12 cases were simultaneously exposed to a variety of medications. There were 3 abortions (one spontaneous and 2 requested by the patients arguing personal reasons). Live born babies without any evidence of major congenital malformations included 8 singleton babies and 2 twins. Of them, 3 babies were born prematurely.

Conclusions: Our results are in agreement with previous large studies where no increased rate of adverse outcomes was reported with the use of inhaled corticosteroids during pregnancy.

MeSH terms

  • Administration, Inhalation
  • Androstadienes / administration & dosage
  • Androstadienes / adverse effects*
  • Androstadienes / immunology
  • Anti-Asthmatic Agents / administration & dosage
  • Anti-Asthmatic Agents / adverse effects*
  • Anti-Asthmatic Agents / immunology
  • Asthma / drug therapy*
  • Asthma / epidemiology
  • Asthma / immunology
  • Female
  • Fluticasone
  • Humans
  • Infant
  • Korea
  • Pregnancy
  • Pregnancy Complications / drug therapy
  • Pregnancy Complications / immunology*
  • Pregnancy Outcome*
  • Rhinitis, Allergic, Perennial / drug therapy*
  • Rhinitis, Allergic, Perennial / epidemiology
  • Rhinitis, Allergic, Perennial / immunology

Substances

  • Androstadienes
  • Anti-Asthmatic Agents
  • Fluticasone