Blurring the Boundary: The Nuclear Envelope Extends Its Reach

Science. 2007 Nov 30;318(5855):1408-12. doi: 10.1126/science.1142034.

Abstract

The past decade has seen a complete rethinking of the traditional view of the nuclear envelope as simply a passive enclosure for the chromosomes. The convergence of several lines of clinical and basic research has revealed additional roles in both signaling and mitotic progression. It is becoming apparent that the nuclear envelope defines not only nuclear organization but also that of the cytoskeleton and, in this way, integrates both nuclear and cytoplasmic architecture.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cytoplasm / physiology
  • Cytoplasm / ultrastructure
  • Cytoskeleton / parasitology
  • Cytoskeleton / physiology
  • Cytoskeleton / ultrastructure
  • Genetic Diseases, Inborn / pathology
  • Genetic Diseases, Inborn / physiopathology
  • Humans
  • Lamins / genetics
  • Mitosis
  • Mutation
  • Nuclear Envelope / physiology*
  • Nuclear Envelope / ultrastructure*
  • Nuclear Lamina / physiology
  • Nuclear Lamina / ultrastructure
  • Nuclear Pore / physiology
  • Nuclear Pore / ultrastructure
  • Signal Transduction
  • Virus Diseases / metabolism
  • Virus Diseases / virology

Substances

  • Lamins