Carboranyl thymidine analogues for neutron capture therapy

Chem Commun (Camb). 2007 Dec 21:(47):4978-91. doi: 10.1039/b707257k. Epub 2007 Aug 15.


Neutron capture therapy (NCT) is a binary radio-chemotherapeutic modality for the treatment of cancer. A major focus of NCT-related research is the development of novel tumor-selective agents that serve as the chemical component in NCT. Thymidine analogues substituted with a boron-containing carborane cluster at the N3 position, designated 3CTAs (3-carboranyl thymidine analogues), constitute one class of these new improved NCT agents. Their chemical, structural and biological properties are discussed in this Feature Article.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Boron / chemistry
  • Boron Compounds / chemistry*
  • Boron Compounds / therapeutic use*
  • Disease
  • Humans
  • Neutron Capture Therapy*
  • Phosphotransferases / metabolism
  • Thymidine / analogs & derivatives*
  • Thymidine / chemistry
  • Thymidine / therapeutic use*


  • Boron Compounds
  • Phosphotransferases
  • Boron
  • Thymidine