The sensory cilia of Caenorhabditis elegans

doi:10.1895/wormbook.1.126.2

Review

. 2007 Mar 8:1-22.

doi: 10.1895/wormbook.1.126.2.

The sensory cilia of Caenorhabditis elegans

Peter N Inglis¹, Guangshuo Ou, Michel R Leroux, Jonathan M Scholey

Affiliations

PMID: 18050505
PMCID: PMC10083726
DOI: 10.1895/wormbook.1.126.2

Review

The sensory cilia of Caenorhabditis elegans

Peter N Inglis et al. WormBook. 2007.

. 2007 Mar 8:1-22.

doi: 10.1895/wormbook.1.126.2.

Authors

Peter N Inglis¹, Guangshuo Ou, Michel R Leroux, Jonathan M Scholey

Affiliation

¹ Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC Canada V5A 1S6.

PMID: 18050505
PMCID: PMC10083726
DOI: 10.1895/wormbook.1.126.2

Abstract

The non-motile cilium, once believed to be a vestigial cellular structure, is now increasingly associated with the ability of a wide variety of cells and organisms to sense their chemical and physical environments. With its limited number of sensory cilia and diverse behavioral repertoire, C. elegans has emerged as a powerful experimental system for studying how cilia are formed, function, and ultimately modulate complex behaviors. Here, we discuss the biogenesis, distribution, structures, composition and general functions of C. elegans cilia. We also briefly highlight how C. elegans is being used to provide molecular insights into various human ciliopathies, including Polycystic Kidney Disease and Bardet-Biedl Syndrome.

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References

1. Albert, P.S., Brown, S.J., and Riddle, D.L. (1981). Sensory control of dauer larva formation in Caenorhabditis elegans. J. Comp. Neurol. 198, 435–451.10.1002/cne.901980305 doi: 10.1002/cne.901980305. - DOI - PubMed
1. Ansley, S.J., Badano, J.L., Blacque, O.E., Hill, J., Hoskins, B.E., Leitch, C.C., Kim, J.C., Ross, A.J., Eichers, E.R., Teslovich, T.M., Mah, A.K., Johnsen, R.C., Cavender, J.C., Lewis, R.A., Leroux, M.R., Beales, P.L., and Katsanis, N. (2003). Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome. Nature 425, 628–633.10.1038/nature02030 doi: 10.1038/nature02030. - DOI - PubMed
1. Apfeld, J., and Kenyon, C. (1999). Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 402, 804–809.10.1038/45544 doi: 10.1038/45544. - DOI - PubMed
1. Ashrafi, K., Chang, F.Y., Watts, J.L., Fraser, A.G., Kamath, R.S., Ahringer, J., and Ruvkun, G. (2003). Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature 421, 268–272.10.1038/nature01279 doi: 10.1038/nature01279. - DOI - PubMed
1. Avidor-Reiss, T., Maer, A.M., Koundakjian, A., Polyanovsky, T., Keil, S., and Zuker, C.S. (2004). Decoding cilia function: defining specialized genes required for compartmentalized cilia biogenesis. Cell 117, 527–529.10.1016/S0092-8674(04)00412-X doi: 10.1016/S0092-8674(04)00412-X. - DOI - PubMed

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[1] Albert, P.S., Brown, S.J., and Riddle, D.L. (1981). Sensory control of dauer larva formation in Caenorhabditis elegans. J. Comp. Neurol. 198, 435–451.10.1002/cne.901980305 doi: 10.1002/cne.901980305. - DOI - PubMed

[2] Albert, P.S., Brown, S.J., and Riddle, D.L. (1981). Sensory control of dauer larva formation in Caenorhabditis elegans. J. Comp. Neurol. 198, 435–451.10.1002/cne.901980305 doi: 10.1002/cne.901980305. - DOI - PubMed

[3] Ansley, S.J., Badano, J.L., Blacque, O.E., Hill, J., Hoskins, B.E., Leitch, C.C., Kim, J.C., Ross, A.J., Eichers, E.R., Teslovich, T.M., Mah, A.K., Johnsen, R.C., Cavender, J.C., Lewis, R.A., Leroux, M.R., Beales, P.L., and Katsanis, N. (2003). Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome. Nature 425, 628–633.10.1038/nature02030 doi: 10.1038/nature02030. - DOI - PubMed

[4] Ansley, S.J., Badano, J.L., Blacque, O.E., Hill, J., Hoskins, B.E., Leitch, C.C., Kim, J.C., Ross, A.J., Eichers, E.R., Teslovich, T.M., Mah, A.K., Johnsen, R.C., Cavender, J.C., Lewis, R.A., Leroux, M.R., Beales, P.L., and Katsanis, N. (2003). Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome. Nature 425, 628–633.10.1038/nature02030 doi: 10.1038/nature02030. - DOI - PubMed

[5] Apfeld, J., and Kenyon, C. (1999). Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 402, 804–809.10.1038/45544 doi: 10.1038/45544. - DOI - PubMed

[6] Apfeld, J., and Kenyon, C. (1999). Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 402, 804–809.10.1038/45544 doi: 10.1038/45544. - DOI - PubMed

[7] Ashrafi, K., Chang, F.Y., Watts, J.L., Fraser, A.G., Kamath, R.S., Ahringer, J., and Ruvkun, G. (2003). Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature 421, 268–272.10.1038/nature01279 doi: 10.1038/nature01279. - DOI - PubMed

[8] Ashrafi, K., Chang, F.Y., Watts, J.L., Fraser, A.G., Kamath, R.S., Ahringer, J., and Ruvkun, G. (2003). Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature 421, 268–272.10.1038/nature01279 doi: 10.1038/nature01279. - DOI - PubMed

[9] Avidor-Reiss, T., Maer, A.M., Koundakjian, A., Polyanovsky, T., Keil, S., and Zuker, C.S. (2004). Decoding cilia function: defining specialized genes required for compartmentalized cilia biogenesis. Cell 117, 527–529.10.1016/S0092-8674(04)00412-X doi: 10.1016/S0092-8674(04)00412-X. - DOI - PubMed

[10] Avidor-Reiss, T., Maer, A.M., Koundakjian, A., Polyanovsky, T., Keil, S., and Zuker, C.S. (2004). Decoding cilia function: defining specialized genes required for compartmentalized cilia biogenesis. Cell 117, 527–529.10.1016/S0092-8674(04)00412-X doi: 10.1016/S0092-8674(04)00412-X. - DOI - PubMed

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The sensory cilia of Caenorhabditis elegans

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The sensory cilia of Caenorhabditis elegans

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