Migraine and the risk of stroke, TIA, or death in the UK (CME)

Headache. Nov-Dec 2007;47(10):1374-84. doi: 10.1111/j.1526-4610.2007.00937.x.


Background: Previous observational studies have reported a higher risk of stroke in migraine patients. Objective.- We aimed to estimate the risk of stroke, transient ischemic attack (TIA), or death in migraineurs in the UK.

Method: We conducted a population-based follow-up study within the General Practice Research Database from 1994 to 2001.

Results: The relative risk (RR) of stroke in migraineurs compared with non-migraineurs was 2.2 (95% confidence interval [CI] 1.7-2.9). It was highest for patients with a migraine diagnosis recorded within 30 days prior to a stroke (odds ratio 11.1, 95% CI 5.69-21.5). The RR of TIA in migraineurs compared with non-migraineurs was 2.4 (95% CI 1.8-3.3), the mortality of migraineurs was slightly decreased.

Conclusion: In our study, the RR of developing a stroke or a TIA was doubled in migraineurs as compared with non-migraineurs, while that for death was close to unity.

MeSH terms

  • Adult
  • Aged
  • Case-Control Studies
  • Databases, Factual / statistics & numerical data
  • Death*
  • Female
  • Humans
  • Ischemic Attack, Transient / epidemiology
  • Ischemic Attack, Transient / etiology
  • Ischemic Attack, Transient / mortality
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Migraine Disorders / complications*
  • Migraine Disorders / epidemiology*
  • Migraine Disorders / mortality
  • Odds Ratio
  • Retrospective Studies
  • Risk*
  • Stroke* / epidemiology
  • Stroke* / etiology
  • Stroke* / mortality
  • United Kingdom / epidemiology